RESPONSE OF HEPATIC MICROBODIES TO A HYPOLIPIDEMIC AGENT, ETHYL CHLOROPHENOXYISOBUTYRATE (CPIB)
نویسندگان
چکیده
منابع مشابه
Response of Hepatic Microbodies to a Hypolipidemic Agent, Ethyl Chlorophenoxyisobutyrate (cpib)
Current knowledge regarding the origin of microbodies, their function in cell metabolism, the manner in which they are destroyed or disposed of by the cell, and their responses to pathological conditions is limited, but emerging information concerning their chemical composition (1, 2), the structure and content of their nucleoid (1, 3-5), and their possible relationship to other cell organelles...
متن کاملMICROBODIES IN EXPERIMENTALLY ALTERED CELLS VII. CPIB-induced Hepatic Microbody Proliferation in the Absence of Significant Catalase Synthesis
Previous studies (1-3) demonstrated a significant increase in number of microbodies (peroxisomes) and concomitant elevation in catalase activity in male rat liver following administration of ethyl-o, p-chlorophenoxyisobutyrate (clofibrate, CPIB), a hypolipidemic drug that lowers serum cholesterol and triglycerides in man (4) and in experimental animals (5, 6) . Neither the significance of micro...
متن کاملMicrobodies in Experimentally Altered Cells
A rapid and sustained increase in the number of microbodies in liver and kidney cells can be induced in male rats by ethyl chlorophenoxyisobutyrate (CPIB), a hypolipidemic drug. This phenomenon permits investigation of several aspects of microbody behavior in experimental conditions. Reversal experiments demonstrate that liver cells revert to normal between 2 and 3 weeks after withdrawal of CPI...
متن کاملEffect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone.
The effect of p-chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-1-(14)C and mevalonate-2-(14)C incorporation studies both in vivo and in vitro confirm the results of other workers that CPIB feeding caused a metabolic block in the conversion of acetate to mevalonate, thereby inhibiting over-all steroidog...
متن کاملNEW OBSERVATIONS ON MICROBODIES A Cytochemical Study on CPIB-Treated Rat Liver
The liver of male rats has been studied after CPIB stimulation by using the peroxidase reaction for localizing catalase in hepatic cells . CPIB administration leads to an increase in the number of microbodies, and it is suggested that one mechanism by which microbody proliferation occurs is a process of fragmentation or budding from preexisting microbodies . Reaction product was observed not on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1966
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.30.2.442